Works with the systems your pharmacy already runs.
MedMe is the clinical and billing layer — not a rip-and-replace. We meet your Rx system, your clearinghouse, your wholesalers, and your payers where they are. Real-time, bidirectional, HIPAA-compliant, and tuned for the way US pharmacy actually operates.
Connected to the dispensing system that runs your store.
Patient demographics, allergies, active medications, dispensing history, and prescriber relationships flow into MedMe automatically. Your pharmacists never re-key — and the chart is always current.
| Rx system | Direction | Sync cadence | What's synced |
|---|---|---|---|
| PioneerRx | ↔ Bidirectional | Real-time webhook | Demographics, Rx history, allergies, refills, fill events |
| BestRx | ↔ Bidirectional | Hourly batch | Demographics, Rx history, allergies, fill events |
| McKesson Pharmacy Manager | → Read | Real-time webhook | Demographics, Rx history, allergies |
| Liberty Software | ↔ Bidirectional | Real-time webhook | Demographics, Rx history, allergies, refills, fill events |
| RxConnect | → Read | Hourly batch | Demographics, Rx history (writeback Q3 2026) |
| QS/1 | → Read | Daily batch | Demographics, Rx history, allergies |
| PrimeRx | → Read | Hourly batch | Demographics, Rx history, allergies |
| Computer-Rx | → Read | Daily batch | Demographics, Rx history |
Whichever clearinghouse you use, MedMe routes through it.
Eligibility (270/271), claims (837P), remittance (835), and claim status (276/277) — all wired into the major US clearinghouses. Bring your existing contract or use a partner clearinghouse we set up during onboarding.
| Clearinghouse | Eligibility (270/271) | Claims (837P) | Remittance (835) | Status (276/277) |
|---|---|---|---|---|
| Change Healthcare | ✓ | ✓ | ✓ | ✓ |
| Availity | ✓ | ✓ | ✓ | ✓ |
| Office Ally | ✓ | ✓ | ✓ | ✓ |
| Waystar | ✓ | ✓ | ✓ | ○ Q3 2026 |
| Trizetto Provider Solutions | ✓ | ✓ | ✓ | ✓ |
Tied into the rest of the supply chain — and the people who pay you.
Wholesalers
| Wholesaler | What's connected |
|---|---|
| AmerisourceBergen (Cencora) | Catalog, contract pricing, ordering EDI |
| McKesson | Catalog, contract pricing, ordering EDI |
| Cardinal Health | Catalog, contract pricing, ordering EDI |
| Smith Drug | Catalog, ordering EDI |
| Anda | Catalog, ordering EDI |
Direct payer connections
| Payer | Coverage |
|---|---|
| Medicare Part B | All MAC jurisdictions |
| BCBS (regional plans) | 34 BCBS plans across US |
| UnitedHealthcare | Medicare Advantage + commercial |
| Humana | Medicare Advantage + commercial |
| Aetna (CVS Health) | Medicare Advantage + commercial |
| Cigna | Commercial + select Medicare |
| Medicaid (state plans) | Configured per pharmacy state |
Don't see your payer? MedMe routes through clearinghouses for any payer with a standard 270/271 EDI envelope — which covers virtually every US plan.
Build whatever else you need.
Beyond the prebuilt integrations, MedMe ships a REST + webhook API for everything: patients, encounters, claims, remittances, immunizations, care plans, eligibility checks. Use it to feed your data warehouse, build a custom patient portal, or wire up a payer your team has a special relationship with.
- OAuth 2.0 with scoped per-tenant tokens
- Webhook-first event streaming (encounter.completed, claim.paid, claim.denied, etc.)
- FHIR R4 endpoints for clinical data exchange
- SDK packages for Node, Python, Ruby, Go
- Sandbox environment with seed data on signup
{
"patient_id": "pat_8f2c01",
"service": "ccm",
"start_at": "2026-05-08T14:32:00Z",
"end_at": "2026-05-08T14:54:00Z",
"pharmacist_npi": "1234567890",
"diagnoses": ["E11.9", "I10"],
"code": "99490",
"minutes": 22,
"place_of_service": "01",
"modifiers": []
}
{
"encounter_id": "enc_2a91f4",
"claim_id": "clm_b81e22",
"status": "submitted",
"estimated_paid_at": "2026-05-22"
}
Full API reference at developers.medmehealth.com
Every integration BAA-protected, every byte encrypted, every action audited.
Read the full security overview · HIPAA documentation · live status
Tell us what you run. We'll tell you what's wired up.
20-minute call. We'll map your Rx system, your clearinghouse, and your top payers — and walk through exactly what onboarding looks like for your setup.